Title of article
Synthesis and in vitro studies of Gd–DTPA derivatives as new potential MRI contrast agents
Author/Authors
Sankar، نويسنده , , Arigala Uma Ravi and Yamasitha، نويسنده , , Mitsuji and Srinivasulu، نويسنده , , Kambam and Ozaki، نويسنده , , Nobuhisa and Aoki، نويسنده , , Takashi and Fujie، نويسنده , , Michio and Ogawa، نويسنده , , Keisuke and Okada، نويسنده , , Shingo and Yamada، نويسنده , , Manubu and Tanaka، نويسنده , , Yasutaka and Kimura، نويسنده , , Motohiko and Toda، نويسنده , , Mitsuo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
2431
To page
2433
Abstract
A new type of dendritic molecules, Gd–DTPA derivatives, which work as a functionalized ligand coordinating gadolinium(III) ion at the center of their frameworks with different terminal moieties on the molecular surfaces, was readily synthesized with high yield. The structures were established by 1H, 13C NMR, and mass spectral studies. In vitro studies showed them to have enhanced r1 value in albumin medium and good potentiality as MRI contrast agent.
Keywords
Gd-complexes , T1 and r1 values , MRI contrast agents , Dendritic ligands
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1872100
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