Title of article
Antitrypanosomal pyridoacridine alkaloids from the Australian ascidian Polysyncraton echinatum
Author/Authors
Feng، نويسنده , , Yunjiang and Davis، نويسنده , , Rohan A. and Sykes، نويسنده , , Melissa L. and Avery، نويسنده , , Vicky M. and Carroll، نويسنده , , Anthony R. and Camp، نويسنده , , David and Quinn، نويسنده , , Ronald J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
3
From page
2477
To page
2479
Abstract
Bioassay-guided fractionation of the crude CH2Cl2/MeOH extract from the Australian ascidian Polysyncraton echinatum led to the isolation of a new pyridoacridine alkaloid, 12-deoxyascididemin (1), along with two known analogues, ascididemin (2) and eilatin (3). The structure of 1 was determined following extensive analysis of 1D/2D NMR and MS data. Biological evaluation showed that compounds 1–3 are potent antitrypanosomal agents with IC50 values of 0.077, 0.032, and 1.33 μM against Trypanosoma brucei brucei, respectively.
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1872113
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