Title of article
Screening of polymeric supports and enzymes for the development of an endo enzyme cleavable linker
Author/Authors
Chiva، نويسنده , , Ana and Williams، نويسنده , , David E. and Tabor، نويسنده , , Alethea B. and Hailes، نويسنده , , Helen C.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
2720
To page
2723
Abstract
Several polymeric supports possessing an ester moiety were prepared and a range of enzymes was investigated to hydrolyse the ester linkage and release a signalling group into solution for applications in immunoassays. Pseudomonas lipases were found to most readily cleave the solution-phase analogue and this observation translated well to the corresponding polymeric supports, where the most effective were PEGA resins and the LPOS support PEG-6000.
Keywords
esterases , Solid-phase reactions , Enzyme cleavable linkers , LPOS , Lipases
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1872179
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