Title of article
Acyl pyruvates as synthons in the Biginelli reaction
Author/Authors
Sergey V. Ryabukhin، نويسنده , , Sergey V. and Plaskon، نويسنده , , Andrey S. and Bondarenko، نويسنده , , Semen S. and Ostapchuk، نويسنده , , Eugeniy N. and Grygorenko، نويسنده , , Oleksandr O. and Shishkin، نويسنده , , Oleg V. and Tolmachev، نويسنده , , Andrey A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
4229
To page
4232
Abstract
Chlorotrimethylsilane-promoted Biginelli-type reaction of ethyl 2,4-dioxo-4-phenylbutanoate, benzaldehyde, and various (thio)ureas is explored. The outcome of the reaction depends on the structure of the (thio)urea used and is strongly affected by the acceptor electronic properties of the COOEt substituent in the molecule of the starting β-dicarbonyl compound. The di- and tetrahydropyrimidine derivatives obtained possess two functional groups with orthogonal reactivity, and thus represent promising building blocks for drug discovery.
Keywords
multicomponent reactions , Heterocycles , Biginelli reaction , Dihydropyrimidines , Acyl pyruvates
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1873959
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