Title of article
A halide-initiated aza-Baylis–Hillman reaction: generation of unnatural amino acids
Author/Authors
Davis، نويسنده , , Lindsey O. and Tobey، نويسنده , , Suzanne L.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
6078
To page
6081
Abstract
A series of allenic ketones react with a glyoxylate-derived imine in the presence of MgBr2 through an aza-Morita–Baylis–Hillman (MBH) reaction. The isolation of a variety of unnatural amino acids with unique allene-containing functional groups provides a conceptually new application of the aza-MBH. The reaction scope and preliminary mechanistic investigations are discussed.
Keywords
Allenic ketones , Lewis acids , Aza-Baylis–Hillman , unnatural amino acids
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1875520
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