Title of article
Synthesis of a tricyclic core of rameswaralide
Author/Authors
Trost، نويسنده , , Barry M. and Nguyen، نويسنده , , Hien M. and Koradin، نويسنده , , Christopher، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
6232
To page
6235
Abstract
A tricyclic core containing a 5,7-fused bicyclic unit of rameswaralide was prepared starting from a 1,6-enyne. The synthetic sequence involved (i) ruthenium-catalyzed [5+2]-cycloaddition of 1,6-enyne, (ii) an acyl radical based approach to construct the lactone, and (iii) a regioselective installation of the conjugated double bond by a concomitant sulfenylation–dehydrosulfenylation sequence.
Keywords
The fused bicyclic system , reductive radical cyclization , total synthesis , cycloaddition , Ruthenium
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1875647
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