Title of article
Kansuinone, a novel euphane-type triterpene from Euphorbia kansui
Author/Authors
Guo، نويسنده , , Jie and He، نويسنده , , Hong-Ping and Fang، نويسنده , , Xin and Di، نويسنده , , Ying-Tong and Li، نويسنده , , Shun-Lin and Zhang، نويسنده , , Zhen and Leng، نويسنده , , Ying and Hua، نويسنده , , Hui-Ming and Hao، نويسنده , , Xiao-Jiang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2010
Pages
4
From page
6286
To page
6289
Abstract
Kansuinone (1), a rearranged euphane triterpenoid containing a spiro [5,6] ring system, was isolated from the roots of Euphorbia kansui. Its structure and stereochemistry were elucidated on the basis of spectroscopic, CD, and computational methods. Kansuinone (1) exhibited inhibitory activity against human and mouse 11β-HSD1 (11β-hydroxysteroid dehydrogenase type 1), with IC50 values of 1.12 and 1.08 μM, respectively.
Keywords
Euphorbia kansui , Euphane-type triterpene , Structure elucidation , 11?-HSD1 inhibitory activity
Journal title
Tetrahedron Letters
Serial Year
2010
Journal title
Tetrahedron Letters
Record number
1875691
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