Title of article
Fragmentations of 13-oxo-taxyunnansin A and their application to preparation of abeo-paclitaxel and abeo-docetaxel analogues
Author/Authors
Zhao، نويسنده , , Yu and Zhang، نويسنده , , Hongbin and Liu، نويسنده , , Ji-Kai and Su، نويسنده , , Jia and Li، نويسنده , , Yan and Yao، نويسنده , , Zhujun and Zhao، نويسنده , , Qin-Shi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
139
To page
142
Abstract
Two interesting unprecedented fragmentations of 13-oxo-taxyunnansin A (3), initiated by treatment with tBuOK and Red-Al, respectively, have been discovered, optimized and successfully applied to the synthesis of novel abeo-paclitaxel and abeo-docetaxel derivatives. Eight new derivatives of abeo-paclitaxel and abeo-docetaxel possessing the structurally simplified 11 (15→1)-abeo-taxane skeleton with an oxetane ring and π bond conjugate system were accordingly prepared for the further evaluation of anticancer activities.
Keywords
fragmentation , abeo-Paclitaxel , Anticancer , Taxyunnansin A , abeo-Taxoids
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1876330
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