Title of article
Non-covalent modification of the active site of cytochrome P450 for inverting the stereoselectivity of monooxygenation
Author/Authors
Fujishiro، نويسنده , , Takashi and Shoji، نويسنده , , Osami and Watanabe، نويسنده , , Yoshihito، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
395
To page
397
Abstract
The enantioselectivity in the sulfoxidation of thioanisole catalyzed by cytochrome P450BSβ with a decoy molecule, a dummy molecule of the natural substrate, can be inverted by changing the structure of the decoy molecule. The methodology demonstrated herein shows the potential for controlling the stereoselectivity of biocatalysts without any mutagenesis.
Keywords
protein modification , Hydrogen peroxide , biocatalyst , cytochrome P450 , Sulfoxidation , stereoselectivity
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1876513
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