Title of article
Toward the optimization of continuous-flow aldol and α-amination reactions by means of proline-functionalized silicon packed-bed microreactors
Author/Authors
Massi، نويسنده , , Alessandro and Cavazzini، نويسنده , , Alberto and Zoppo، نويسنده , , Luisa Del and Pandoli، نويسنده , , Omar and Costa، نويسنده , , Valentina and Pasti، نويسنده , , Luisa and Giovannini، نويسنده , , Pier Paolo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
619
To page
622
Abstract
The activity and stability under flow conditions of covalently and non-covalently silica supported proline and proline-like organocatalysts is herein described. The slow aldol reaction of cyclohexanone with p-nitro benzaldehyde and the fast α-amination of isovaleraldehyde with dibenzyl azodicarboxylate have been selected as model reactions for this study. Prospects and limitations of the disclosed continuous-flow organocatalytic approach are widely discussed.
Keywords
Continuous-flow processes , Microreactors , organocatalysis , Asymmetric catalysis
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1876692
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