Title of article
Rhodium-catalyzed asymmetric addition of arylboronic acids to γ-phthalimido-substituted-α,β-unsaturated carboxylic acid esters: an approach to γ-amino acids
Author/Authors
Han، نويسنده , , Fuzhong and Chen، نويسنده , , Jun and Zhang، نويسنده , , Xiangyang and Liu، نويسنده , , Jibing and Cun، نويسنده , , Linfeng and Zhu، نويسنده , , Cui-Jin and Deng، نويسنده , , Jingen and Liao، نويسنده , , Jian، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
830
To page
833
Abstract
Efficient Rh-catalyzed asymmetric 1,4-addition of arylboronic acids to ethyl-γ-phthalimidocrotonate by using bis-sulfoxide ligand affords γ-aminobutyric acid (GABA) derivatives with high enantioselectivities (90–96% ee) under mild conditions. Optically pure (S)-Baclofen and (S)-Rolipram have been prepared successfully through this synthetic route.
Keywords
1 , 4-addition , ?-Aminobutyric acids , Bis-sulfoxide ligand , Rh-catalyzed
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1876878
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