Title of article
Synthesis of (2S)-isopropyl-5-alkynylpyrimidin-2-ones: precursors of β-aminoacids
Author/Authors
Stefani، نويسنده , , Hélio A. and Amaral، نويسنده , , Monica F.Z.J. and Juaristi، نويسنده , , Eusebio، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
6
From page
1014
To page
1019
Abstract
The efficient palladium-catalyzed Suzuki-Miyaura cross-coupling reaction of (2S)-isopropyl-5-iodo-2,3-dihydro-4(H)-pyrimidin-4-one with, arylethynyl-, heteroarylethynyl-, and alkylethynyltrifluoroborate salts is reported. The standard protocol was evaluated and optimized in order to gain access to suitable precursors of enantiopure 2-substituted β-amino acids. The scope and limitations of this methodology are discussed.
Keywords
Suzuki-Miyaura , 5-Iodopyrimidinone , ?-Aminoacids , cross-coupling reaction , Alkynyltrifluoroborates
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877016
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