Title of article
Screening method for the evaluation of asymmetric catalysts for the reduction of aliphatic ketones
Author/Authors
Boukachabia، نويسنده , , Mourad and Zeror، نويسنده , , Saoussen and Collin، نويسنده , , Jacqueline and Fiaud، نويسنده , , Jean-Claude and Zouioueche، نويسنده , , Louisa Aribi-Zouioueche، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
1485
To page
1489
Abstract
ATH reductions of aliphatic ketones in water catalyzed by ruthenium coordinated by prolinamide ligands produce alcohols with moderate enantiomeric excesses in most cases. A set of seven aliphatic ketones is proposed for a rapid evaluation of the enantioselectivity of catalysts by one-pot multi-substrates reduction. The screening of a library of prolinamides shows that according to the structure of the ketones different ligands give the best asymmetric inductions.
Keywords
Multi-substrate screening , Aliphatic ketones , Asymmetric catalysis , Ruthenium , hydride transfer
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877385
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