Title of article
A novel method to enable SNAr reaction of aminopyrrolopyrazoles
Author/Authors
Guo، نويسنده , , Chuangxing and Dong، نويسنده , , Liming and Marakovits، نويسنده , , Joseph and Kephart، نويسنده , , Susan، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
1692
To page
1696
Abstract
Here we report mild, environmentally-friendly reaction conditions which enable the addition–elimination SNAr reaction between weakly reactive substrates––an aminopyrrolopyrazole template and several substituted pyrimidines. The method was developed during our efforts to synthesize a series of novel P21-activated kinase (PAK) inhibitors.
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877548
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