Title of article
Total synthesis of topsentolide B2
Author/Authors
Fernandes، نويسنده , , Rodney A. and Kattanguru، نويسنده , , Pullaiah، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
1788
To page
1790
Abstract
A stereoselective total synthesis of topsentolide B2, a selective cytotoxic oxylipin against SK-OV-3 and SK-MEL-2 cancer cell lines has been achieved based on asymmetric dihydroxylation, Roush allylation, and ring closing metathesis (RCM) reactions. The synthesis is completed in 11 steps and 2.1% overall yield.
Keywords
Asymmetric dihydroxylation , Roush allylation , Ring closing metathesis (RCM) , Topsentolides , stereoselective synthesis
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1877607
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