Title of article
Facile reaction of carboxylic acids with isonitriles in toluene
Author/Authors
Polisar، نويسنده , , Jason G. and Li، نويسنده , , Ling and Norton، نويسنده , , Jack R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
2
From page
2933
To page
2934
Abstract
Isonitriles react with low concentrations of carboxylic acids in toluene at 110 °C to give N-formylamides in yields generally above 70%. These concentrations can be obtained either by syringe pump addition of a toluene solution of the acid, or by using a suspension of the acid if it has limited solubility in toluene at room temperature.
Keywords
Isonitriles , N-Formylamides , Two component coupling , peptide synthesis
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878416
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