A novel highly stereoselective multi-component synthesis of N-substituted β-amino ketone derivatives using copper(II) phthalocyanine as reusable catalyst

Stereoselective synthesis of N-substituted β-amino ketone derivatives with substituents include one or two polar hetero atoms on benzene rings in many cases has been achieved by a one-pot multi-component process using copper(II) phthalocyanine as catalyst. The new process is suitable for the inclusion of a wide variety of substrates for the construction of highly functionalized Mannich-type structural scaffolds. The catalyst used is recycled and reused for repeating the reactions.