Title of article
Synthesis of difluoromethylphosphonamidates by direct addition of amine
Author/Authors
Aliouane، نويسنده , , Lucie and Rigaud، نويسنده , , Baptiste and Pfund، نويسنده , , Emmanuel and Jean، نويسنده , , Ludovic and Renard، نويسنده , , Pierre-Yves and Lequeux، نويسنده , , Thierry، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
3681
To page
3685
Abstract
The one step synthesis of difluoromethylphosphonamidates from dialkylphosphonates is reported. The addition of lithiated amides onto dialkyl difluoromethylphosphonates afforded the corresponding phosphonamidates, as potential prodrug precursors. The remarkable high stability of these phosphonamidates in acidic medium was studied by 31P NMR.
Keywords
Difluorophosphonate , Phosphorus , Phosphonamidate , fluorine
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878749
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