Title of article
Bromination of 3-substituted benzo[b]thiophenes: access to Raloxifen intermediate
Author/Authors
Liger، نويسنده , , François and Pellet-Rostaing، نويسنده , , Stéphane and Popowycz، نويسنده , , Florence and Lemaire، نويسنده , , Marc، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
3736
To page
3739
Abstract
A practical route to prepare halogeno-derivatives is described, starting from easily available 3-cyano-benzo[b]thiophene. Main efforts have been devoted to the optimization of the experimental procedures (solvent, bromination) to promote selectivity. Synthetic studies investigate the potential access to an advanced intermediate of Raloxifen.
Keywords
Raloxifen , Electrophilic aromatic substitution , Bromination
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878773
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