Title of article
A diversity-oriented-synthesis protocol for scaffold discovery based on a general synthetic route to spirocycles
Author/Authors
Kang، نويسنده , , Fu-An and Sui، نويسنده , , Zhihua، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
4204
To page
4206
Abstract
A diversity-oriented synthesis (DOS) protocol for scaffold discovery is described. A general synthetic route is developed from a single lactam for the access to various multi-functionalized spirocyclic keto-lactams and their derived spirocyclic keto-amines. This work provides the foundation for a sequential DOS strategy from scaffold discovery to drug discovery.
Keywords
diversity-oriented synthesis , scaffold discovery , Drug discovery , Library design , spirocycle
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878978
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