Title of article
A new synthesis of the orally active renin inhibitor aliskiren
Author/Authors
Slade، نويسنده , , Joel and Liu، نويسنده , , Hui and Prashad، نويسنده , , Mahavir and Prasad، نويسنده , , Kapa، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
4349
To page
4352
Abstract
A convergent synthesis of the orally active renin inhibitor aliskiren (1) is described. The synthesis was accomplished in 12 steps starting from the known chloride 2. The key step involves the Curtius rearrangement of the advanced intermediate 15, which provides lactone/carbamate 17 containing the correct stereochemistry and all of the functionality required for the preparation of the drug substance.
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879041
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