Title of article
A highly enantioselective Diels–Alder reaction of 1,2-dihydropyridine using a simple β-amino alcohol organocatalyst for a practical synthetic methodology of oseltamivir intermediate
Author/Authors
Chonticha Suttibut، نويسنده , , Chonticha and Kohari، نويسنده , , Yoshihito and Igarashi، نويسنده , , Ko and Nakano، نويسنده , , Hiroto and Hirama، نويسنده , , Masafumi and Seki، نويسنده , , Chigusa and Matsuyama، نويسنده , , Haruo and Uwai، نويسنده , , Koji and Takano، نويسنده , , Nobuhiro and Okuyama، نويسنده , , Yuko and Osone، نويسنده , , Kenichi and Takeshita، نويسنده , , Mitsuhiro and Kwon، نويسنده , , Eunsang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
4745
To page
4748
Abstract
An easily prepared chiral amino alcohol catalyst was found to provide an efficient synthetic intermediate of oseltamivir with excellent chemical yield and enantioselectivity (up to 98% yield and up to 98% ee) in enantioselective Diels–Alder reactions of 1,2-dihydropylidines with acroleins.
Keywords
organocatalyst , ?-Amino alcohol , Diels–Alder reaction , 1 , 2-dihydropyridine , Isoquinuclidine
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879205
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