Title of article
Enantioselective addition of phenylacetylene to aldehydes catalyzed by a d-glucosamine-derived sulfonamide–titanium complex
Author/Authors
Bauer، نويسنده , , Tomasz G. Smolinski، نويسنده , , S?awomir and Gawe?، نويسنده , , Przemys?aw and Jurczak، نويسنده , , Janusz، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
4882
To page
4884
Abstract
We present the synthesis of β-hydroxy sulfonamides derived from d-glucosamine and their application as ligands in titanium tetraisopropoxide promoted enantioselective addition of phenylacetylene to benzaldehyde and selected aromatic and aliphatic aldehydes. The N-3,5-bis(trifluoromethyl)benzenesulfonamido-d-glucosamine derivative was chosen as the most efficient ligand for this addition. The reaction is highly enantioselective for several aromatic aldehydes and enantiomeric excesses up to 92% were obtained.
Keywords
d-glucosamine , Aldehydes , phenylacetylene , enantioselective
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879243
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