Title of article
Ring opening of cyclic sulfamidates with bromophenyl metal reagents: complementarity of sulfamidates and aziridines
Author/Authors
Hebeisen، نويسنده , , Paul S. Weiss، نويسنده , , Urs and Alker، نويسنده , , André and Staempfli، نويسنده , , Andreas، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
5229
To page
5233
Abstract
Bromophenyl magnesium reagents generated via a Knochel type magnesium–halogen exchange of aryl iodides undergo regioselective ring opening of cyclic primary and secondary N-Boc sulfamidates in good to excellent yields. With secondary sulfamidates the reaction proceeds with clean inversion of the stereochemistry. This protocol complements the ring opening of aziridines with bromophenyl metal reagents and extends its scope to secondary substrates.
Keywords
Cyclic sulfamidate , aziridine , regioselectivity , stereoselectivity , Knochel Grignard
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879332
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