Title of article
Phosphoramidites based on phenyl-substituted 1,2-diols as ligands in palladium-catalyzed asymmetric allylations: the contribution of steric demand and chiral centers to the enantioselectivity
Author/Authors
Gavrilov، نويسنده , , Konstantin N. and Zheglov، نويسنده , , Sergey V. and Gavrilova، نويسنده , , Mariya N. and Chuchelkin، نويسنده , , Ilya V. and Groshkin، نويسنده , , Nikolay N. and Rastorguev، نويسنده , , Eugenie A. and Davankov، نويسنده , , Vadim A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
5706
To page
5710
Abstract
A small family of readily available phosphoramidite ligands, including compounds with P∗-stereocenters, has been prepared from phenyl-substituted 1,2-diols as simple and cheap starting materials. Using these ligands, up to 84% ee was achieved in Pd-catalyzed asymmetric allylic substitution. The influence of structural modules such as asymmetric atoms and steric demand on the enantioselectivity is discussed.
Keywords
Phosphoramidites , Asymmetric allylic substitution , PALLADIUM , Phosphorus ligands
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879448
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