Title of article
Total synthesis of (−)-nakadomarin A: alkyne ring-closing metathesis
Author/Authors
Jakubec، نويسنده , , Pavol and Kyle، نويسنده , , Andrew F. and Calleja، نويسنده , , Jonلs and Dixon، نويسنده , , Darren J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
6094
To page
6097
Abstract
A 13-step, highly stereoselective synthesis of (−)-nakadomarin A has been achieved using the combination of a bifunctional organocatalyst controlled Michael addition, a nitro-Mannich/lactamization cascade, an alkyne ring-closing metathesis/syn-reduction, and furan/iminium ion cyclization/reduction as key steps.
Keywords
nakadomarin A , total synthesis , organocatalysis , stereoselective synthesis , Michael addition , Nitro-Mannich reaction , iminium ion , Alkyne ring-closing metathesis , Cascade
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879542
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