Title of article
Facile synthesis of 3-aryl/alkylamino 5-aryl/alkyl 1,2,4-oxadiazoles from acylthiourea
Author/Authors
Chennakrishnareddy، نويسنده , , Gundala and Debasis، نويسنده , , Hazra and Jayan، نويسنده , , Rapai and Manjunatha، نويسنده , , Sulur G. and Sridharan، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
6170
To page
6173
Abstract
Facile and selective synthesis of 3-aryl/alkylamino 5-aryl/alkyl 1,2,4-oxadiazoles starting from N-acylthioureas has been demonstrated. The regio-selectivity is achieved by simply selecting an appropriate base used for the generation of hydroxyl amine from the corresponding hydrochloride salt. This method also avoids the use of toxic cyanogen bromide. The structure of the synthesized oxadiazoles has been resolved by tandem mass spectral studies.
Keywords
1 , 2 , 4-oxadiazoles , Acylthiourea , Hydroxylamine hydrochloride , Acylisothiocyanate
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879560
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