Title of article
Synthesis of the C21–C34 fragment of antascomicin B
Author/Authors
Hutchison، نويسنده , , John M. and Gibson، نويسنده , , Andrew S. and Williams، نويسنده , , David T. and McIntosh، نويسنده , , Matthias C.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
6349
To page
6351
Abstract
The C21–C34 fragment of the potent FKBP12-binding macrolide antascomicin B was prepared using Ireland-Claisen and allylic diazene rearrangements to establish the C26/C27 and the C23 stereocenters, respectively. Directed hydrogenation installed the C29 β-configuration. The fragment possesses 7 of the 11 fixed stereocenters contained in the natural product.
Keywords
natural product , Directed hydrogenation , Ireland-Claisen rearrangement , Allylic diazene rearrangement
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879601
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