• Title of article

    Asymmetric synthesis of (−)-codonopsinine

  • Author/Authors

    Davies، نويسنده , , Stephen G. and Lee، نويسنده , , James A. and Roberts، نويسنده , , Paul M. and Thomson، نويسنده , , James E. and West، نويسنده , , Callum J.، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2011
  • Pages
    4
  • From page
    6477
  • To page
    6480
  • Abstract
    The asymmetric synthesis of (−)-codonopsinine was achieved in 7 steps (from commercially available tert-butyl crotonate) in 5% overall yield and >99:1 dr. The key step in this synthesis involved ring-closing iodoamination of a functionalised homoallylic amine, which occurred with concomitant N-debenzylation, to give a 3-iodopyrrolidine that was elaborated to (−)-codonopsinine.
  • Keywords
    (?)-Codonopsinine , Ring-closing iodoamination , pyrrolidine , Lithium amide
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2011
  • Journal title
    Tetrahedron Letters
  • Record number

    1879634

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1879634