Title of article
Stereoselective synthesis of analogs of the macrolactone of isomigrastatin
Author/Authors
Dias، نويسنده , , Luiz C. and Monteiro، نويسنده , , Gustavo C. and Amarante، نويسنده , , Giovanni W. and Conegero، نويسنده , , Leila S. and Finelli، نويسنده , , Fernanda G.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
707
To page
709
Abstract
An approach for the highly stereoselective synthesis of analogs of the macrolactone of isomigrastatin is described. Our optimized strategy is based on a very efficient lactone opening, a Wittig olefination reaction and a ring closing metathesis. The syntheses were accomplished in 10–11 steps and good overall yields.
Keywords
Dihydroxilation reaction , Ring closing metathesis , macrolactone , Tumor metastasis , Migrastatin
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880076
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