Title of article
Application of [BoPhoz Rh] catalysts in the asymmetric hydrogenation of a pyridyl benzothiophene alkene
Author/Authors
Gross، نويسنده , , Timothy and Chou، نويسنده , , Shine and Dyke، نويسنده , , Alan and Dominguez، نويسنده , , Beatriz and Groarke، نويسنده , , Michelle and Medlock، نويسنده , , Jonathan and Ouellette، نويسنده , , Michael and Reddy، نويسنده , , Jayachandra P. and Seger، نويسنده , , Andreas and Zook، نويسنده , , Scott and Zanotti-Gerosa، نويسنده , , Antonio، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
1025
To page
1028
Abstract
The asymmetric hydrogenation of a pyridyl benzothiophene alkene has been successfully accomplished using [BoPhoz Rh] catalysts. By tailoring the steric properties of the BoPhoz ligand, the ee of the product could be increased from just 12% to 90%. This research further expands the substrate scope of the conventional class of functionalized alkenes amenable to catalytic asymmetric hydrogenation.
Keywords
Homogeneous asymmetric hydrogenation , Enantioselective hydrogenation of alkenes , BoPhoz ligands , rhodium catalysts
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880175
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