Title of article
Auxiliary-directed oxidation of ursolic acid by ‘Ru’-porphyrins: chemical modulation of cytotoxicity against tumor cell lines
Author/Authors
Tanaka، نويسنده , , Katsunori and Mazumder، نويسنده , , Kishor and Siwu، نويسنده , , Eric R.O. and Nozaki، نويسنده , , Satoshi and Watanabe، نويسنده , , Yasuyoshi and Fukase، نويسنده , , Koichi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
1756
To page
1759
Abstract
Derivatization of ursolic acid, one of the natural ursene-type pentacyclic triterpenes, was investigated by the oxidation with dioxoruthenium(VI) tetraphenylporphyrins. Oxidation selectivity on the terpene structure was modulated by the auxiliaries introduced on the tetraphenylporphyrin. Chemical oxidation of the ursolic acid affected the cytotoxic activity against tumor cell lines.
Keywords
Ursolic acid , Dioxoruthenium(VI) tetraphenylporphyrin , cytochrome P450 , Biomimetic oxidation , cytotoxicity
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880401
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