Title of article
Enantioselective intramolecular α-amidoalkylation reaction in the synthesis of pyrrolo[2,1-a]isoquinolines
Author/Authors
Gَmez-SanJuan، نويسنده , , Asier and Sotomayor، نويسنده , , Nuria and Lete، نويسنده , , Esther، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
2157
To page
2159
Abstract
BINOL-derived chiral Brønsted acids are capable of carrying out the intramolecular α-amidoalkylation of a tertiary N-acyliminium ions when a methoxylated benzene ring is used as internal π nucleophile. The reaction can be applied to the synthesis of pyrrolo[2,1-a]isoquinolines and use of the sterically congested acid 3e is determinant to obtain good levels of enantioselection.
Keywords
N-acyliminium ions , ?-Amidoalkylation , Br?nsted acids , Asymmetric catalysis
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880581
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