Title of article
Synthesis and biological evaluation of cremastrine and an unnatural analogue
Author/Authors
Hahn، نويسنده , , Kristopher N. and Fadeyi، نويسنده , , Olugbeminiyi O. and Cho، نويسنده , , Hyekyung P. and Lindsley، نويسنده , , Craig W.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
3577
To page
3580
Abstract
In this Letter, we describe the first total synthesis of cremastrine, a pyrrolizidine alkaloid from Cremastra appendiculata, with anticholinergic activity as well as an unnatural analogue. The streamlined synthesis proceeds in nine steps, seven steps longest linear sequence, in 25.2% overall yield, and features novel methodology to construct the pyrrolizidine core. Biological evaluation of cremastrine and the unnatural analogue indicated that both are pan-mAChR functional antagonists.
Keywords
Mitsunobu , Pyrrolizidine , Anticholinergic , Sulfinimine , Cremastrine
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881154
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