Title of article
sp3 C–H bond functionalization of methyl n-alkyl ketones [MeCOCnH2n+1 (n = 6–8)] as a novel method for the one-pot regioselective synthesis of ‘bifunctional alkanes’ with remote functional groups
Author/Authors
Akhrem، نويسنده , , Irena S. and Afanas’eva، نويسنده , , Lyudmila V. and Kagramanov، نويسنده , , Nikolai D. and Petrovskii، نويسنده , , Pavel V.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
4221
To page
4224
Abstract
Selective one-pot functionalization of methyl n-alkyl ketones, CnH2n+1COMe (n = 6–8) involving C-sp3–H bond cleavage with CO and various nucleophilic substrates [iPrOH, BuCH(Et)CH2OH, CF3CH2OH, (CF3)(Me)CHOH, H(CF2)2CH2OH, HCCCH2OH, furan, thiophene, and anisole] in the presence of the superelectrophilic system CBr4·2AlBr3 has been performed for the first time.
Keywords
Functionalized ketones , n-Alkyl methyl ketones , Functionalization , Superelectrophiles
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881461
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