Title of article
Solid-phase synthesis of benzothiazoles using an alkoxyamine linker
Author/Authors
Hioki، نويسنده , , Hideaki and Matsushita، نويسنده , , Kimihito and Noda، نويسنده , , Takeshi and Yamaguchi، نويسنده , , Kota and Kubo، نويسنده , , Miwa and Harada، نويسنده , , Kenichi and Fukuyama، نويسنده , , Yoshiyasu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
6
From page
4337
To page
4342
Abstract
An alkoxyamine linker was applied for the solid-phase synthesis of benzothiazoles. The substrate was anchored by aldoxime linkage and products were cleaved from the solid-support by aldoxime–imine exchange coupled with air-oxidation under the weakly acidic conditions. The tether is highly robust under Mitsunobu reaction, nucleophilic substitution reaction, and Pd-catalyzed reaction conditions.
Keywords
Mitsunobu reaction , benzothiazole , Alkoxyamine linker , Pd-catalyzed reaction , solid-phase synthesis
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881516
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