Title of article
An alternative strategy to the Pictet–Spengler method for tetrahydroisoquinoline synthesis: a feasibility study
Author/Authors
Henderson، نويسنده , , Laura and Knight، نويسنده , , David W. and Williams، نويسنده , , Andrew C.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
4657
To page
4660
Abstract
Acid-catalysed cyclisations of the 2-aminoethyl styrene derivatives 9 give good to excellent yields of the corresponding tetrahydroisoquinolines 7 by an intramolecular hydroamination reaction, which represents an alternative and potentially more flexible strategy to the classical Pictet–Spengler method for the syntheses of such heterocycles.
Keywords
Cyclisation , Pictet–Spengler , Hydroamination , Acid-catalysed , Alternative
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881648
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