Title of article
Multi-gram synthesis of a porphyrazine platform for cellular translocation, conjugation to Doxorubicin, and cellular uptake
Author/Authors
Trivedi، نويسنده , , Evan R. and Blumenfeld، نويسنده , , Carl M. and Wielgos، نويسنده , , Todd and Pokropinski، نويسنده , , Sharon and Dande، نويسنده , , Prasad and Hai، نويسنده , , Ton T. and Barrett، نويسنده , , Anthony G.M. and Hoffman، نويسنده , , Brian M.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
5475
To page
5478
Abstract
We report the synthesis of the near infrared (NIR) fluorescent porphyrazine (Pz) 285, with pendant hydroxyl groups, as a non-toxic platform for delivery of conjugated chemotherapeutic agents to tumor cells. Conjugation of Pz 285 to Doxorubicin via an acid labile linker and initial biological studies are reported.
Keywords
tetrapyrrole , porphyrinoid , chemotherapy
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882220
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