Title of article
An intramolecular nitro-Mannich route to functionalised tetrahydroquinolines
Author/Authors
Anderson، نويسنده , , James C. and Noble، نويسنده , , Adam and Torres، نويسنده , , Pascual Ribelles، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
5707
To page
5710
Abstract
A simple protocol for the diastereoselective synthesis of 3-nitrotetrahydroquinolines has been developed using an intramolecular nitro-Mannich reaction. In situ formation of an imine generated from treatment of 2-(2-nitroethyl)phenylamine with an aldehyde, in EtOH at room temperature, and subsequent addition of NH4OH, led to the formation of trans-products in high yield and diastereoselectivity for 15 representative examples.
Keywords
Cyclisation , heterocycle , Nitro-Mannich , Tetrahydroquinoline , diastereoselective
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1882361
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