Title of article
Convenient synthesis and cyclization of dimeric abasic PNA
Author/Authors
Cooper، نويسنده , Paul W , Daniel C. and Suggs، نويسنده , , J. William، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
6943
To page
6945
Abstract
The synthesis of an abasic PNA-based dimer block has been achieved. An alkyl chain stapling the two base sites conformationally restricts the PNA backbone, and serves as an example of preorganization by direct base site linkage. Other possible examples of this strategy, such as enforced stacking of adjacent intrastrand bases to give base pair step analogs, are put forward.
Keywords
Base pair step , peptide nucleic acid , stacking , DNA analog
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1883048
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