Title of article
Stereochemistry of theonezolides A–C
Author/Authors
Nozawa، نويسنده , , Kohei and Tsuda، نويسنده , , Masashi and Tanaka، نويسنده , , Naonobu and Kubota، نويسنده , , Takaaki and Fukushi، نويسنده , , Eri and Kawabata، نويسنده , , Jun-ka Kobayashi، نويسنده , , Jun’ichi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
5
From page
783
To page
787
Abstract
Theonezolides A–C (1–3) are cytotoxic 37-membered macrolides with a long side chain isolated from an Okinawan marine sponge Theonella sp. The relative stereochemistry of 1–3 was investigated by combination of NMR analysis including application of a JBCA method, a Universal NMR database, and a 13C-acetonide method. Furthermore, the absolute configurations at 14 chiral centers in 1–3 were found to be 19S, 22R, 24S, 28S, 44S, 45S, 47R, 49S, 53R, 55S, 57S, 59S, 60S, and 63S by application of a modified Mosher’s method.
Keywords
Theonezolides A–C , JBCA method , Universal NMR Database , 13C-acetonide method , Stereochemistry
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1883649
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