Title of article
A short and straightforward approach towards 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines
Author/Authors
Stella، نويسنده , , Alessandro and De Jonghe، نويسنده , , Steven and Segers، نويسنده , , Kenneth and Herdewijn، نويسنده , , Piet، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
830
To page
833
Abstract
A facile and efficient synthesis of 6-amino and 6-aminoalkyl thiazolo[4,5-c]pyridazines is reported. The key step for the construction of this novel bicyclic scaffold was the reaction between 3-amino-4-bromopyridazine derivatives and alkylisothiocyanates. The application of this methodology for the synthesis of a small library of thiazolo[4,5-c]pyridazines is also described.
Keywords
Isothiocyanates , 5-c]pyridazine , Privileged structures , Drug-like structures
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1883667
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