Title of article
Intramolecular cyclization of N-propargylic β-enaminones catalyzed by silver
Author/Authors
Martins، نويسنده , , Marcos A.P. and Rossatto، نويسنده , , Marcelo and Frizzo، نويسنده , , Clarissa P. and Scapin، نويسنده , , Elisandra and Buriol، نويسنده , , Lilian and Zanatta، نويسنده , , Nilo and Bonacorso، نويسنده , , Helio G.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
847
To page
849
Abstract
The efficient synthesis of 1,2-dihydropyridine from the intramolecular cyclization reaction of N-propargylic β-enaminones [R2C(O)CHC(R1)(N(R)CH2CCH), where R = Pr, Bn, Ph, 4-Me-C6H4, R1 = Me, Et, Pr, R2 = CF3, CO2Et] using AgNO3 as a catalyst (12 h at 25 °C) is reported. The products were obtained at good yields (70–90%). In particular, when the reaction of N-propargylic β-enaminone with R = Me was performed over a 24 h period, the intramolecular cyclization resulted in the formation of a pyrrole with 80% yield.
Keywords
Intramolecular cyclization , N-Propargylic ?-enaminones , 1 , 2-dihydropyridine , pyridine , pyrrole
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1883677
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