Title of article
Room temperature catalyst-free Knoevenagel condensation: facile access to isatinylidenerhodanines
Author/Authors
Xue، نويسنده , , Fengtian and MacKerell Jr.، نويسنده , , Alexander D. and Heinzl، نويسنده , , Geoffrey K. Hom، نويسنده , , Kellie، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
1700
To page
1703
Abstract
A catalyst-free Knoevenagel type synthesis of isatinylidenerhodanines is reported starting from substituted isatins and rhodanines. The reaction proceeds spontaneously at room temperature in dimethyl sulfoxide (DMSO), employing a unique macrocyclic intermediate formed through an intramolecular H-bonding. Various substituted isatinylidenerhodanines could be synthesized in good yields.
Keywords
BCL6 inhibitors , Bürgi–Dunitz trajectory , catalyst-free , Knoevenagel condensation , Isatinylidenerhodanines
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884086
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