An unusual intramolecular Diels–Alder approach toward maoecrystal V

Intramolecular Diels–Alder reactions are commonly employed for the synthesis of polycyclic natural products, but the use of aldehydes as dienophiles is an underexplored facet of the intramolecular cycloaddition. The intramolecular nature of this reaction allowed the use of aldehydes as dienophiles without the use of highly activated dienes, as is often necessary for intermolecular Diels–Alder reactions with aldehydes. A synthetic route to maoecrystal V is explored utilizing this new chemistry.