Title of article
Organocatalytic enantioselective transient enolate protonation in conjugate addition of thioacetic acid to α-substituted N-acryloyloxazolidinones
Author/Authors
Nirmal K. and Unhale، نويسنده , , Rajshekhar A. and Rana، نويسنده , , Nirmal K. and Singh، نويسنده , , Vinod K.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
5
From page
1911
To page
1915
Abstract
Organocatalytic conjugate addition of thioacetic acid to a series of α-substituted N-acryloyloxazolidin-2-ones followed by enantioselective protonation has been studied in the presence of thiourea catalysts derived from cinchona alkaloids. Conjugate addition/protonation adducts have been obtained up to 97% ee and high yields. The methodology could serve as an easy and practical route to the syntheses of useful biologically active molecules.
Keywords
organocatalyst , Thiourea , Sulfa-Michael , ?-Substituted N-acryloyloxazolidinones , thioacetic acid
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884155
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