Title of article
Fast thiol–maleamic methyl ester addition for facile covalent cross-linking of oligonucleotides
Author/Authors
Cao، نويسنده , , Liqiang and Xi، نويسنده , , Zhen، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
5
From page
1916
To page
1920
Abstract
Thiol-Michael-cross-linked oligodeoxynucleotides were synthesized through the thiol–maleamic acid methyl ester addition reaction. As a metal-free ‘click’ reaction, the cross-linked method was fast responsive and highly sensitive. The newly synthesized oligodeoxynucleotides were thermally stable and their global structures retained those of non-cross-linked oligodeoxynucleotides and showed responsive reaction to different DNA restriction enzymes.
Keywords
Thiol-Michael-cross-linked oligodeoxynucleotides , Metal-free ‘click’ reaction , thermal stability , DNA Restriction Enzyme
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884156
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