Title of article
Thermally driven asymmetric domino reaction catalyzed by a thermostable esterase and its variants
Author/Authors
Wada، نويسنده , , Reina and Kumon، نويسنده , , Takashi and Kourist، نويسنده , , Robert and Ohta، نويسنده , , Hiromichi and Uemura، نويسنده , , Daisuke and Yoshida، نويسنده , , Shosuke and Miyamoto، نويسنده , , Kenji، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
3
From page
1921
To page
1923
Abstract
We have developed a thermally driven domino reaction for the synthesis of (S)-α-arylpropionates (profens) using a thermostable esterase from Sulfolobus tokodaii strain 7. Stereoselectivity was improved considerably by engineering of the active site. Stereoselective decarboxylation at the active site of an esterase is a new reaction for the synthesis of optically active carboxylic acids.
Keywords
Domino reaction , Thermostable esterase , Thermal spontaneous decarboxylation , ?-Arylpropionates , Active site
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884157
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