Title of article
Organocatalytic enantioselective conjugate addition of 2-nitrocyclohexanone to acrylaldehyde: a concise two-step synthesis of chiral building block 1-azaspiro[4.5]decan-6-one
Author/Authors
Ding، نويسنده , , Xiaohua and Cui، نويسنده , , Weichen and Li، نويسنده , , Xiang and Ju، نويسنده , , Xuan and Liu، نويسنده , , Dan and Wang، نويسنده , , Shaozhong and Yao، نويسنده , , Zhu-Jun، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2013
Pages
4
From page
1956
To page
1959
Abstract
A gram-scale organocatalytic enantioselective Michael addition of α-nitrocyclohexanone to acrolein has been developed, and it was successfully applied to a concise two-step synthesis of (1S)-azaspiro[4.5]decan-6-one, a useful chiral building block for the synthesis of a variety of natural alkaloids.
Keywords
enantioselective synthesis , Michael addition , Building block , organocatalysis
Journal title
Tetrahedron Letters
Serial Year
2013
Journal title
Tetrahedron Letters
Record number
1884173
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