Synthesis and investigation of 1,6-bis-di-tert-butylphosphinohexane and its application in Suzuki–Miyaura coupling

Palladium catalysts have excellent compounds used in generating difficult carbon–carbon bonds. The development of these palladium catalysts has been the attention of much research. The use of alkyl-phosphines has led to many very active, bulky ligands for palladium catalysts. We report a convenient synthesis of 1,6-bis-di-tert-butylphosphinohexane (DTBPH) and its evaluation in palladium catalyzed Suzuki–Miyaura coupling. The combination of DTBPH and palladium has led to excellent productivity when used as catalyst for Suzuki coupling.